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- Impact of exercise on health outcomes in people with cancer: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials
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Systematic review
Impact of exercise on health outcomes in people with cancer: an umbrella review of systematic reviews and meta-analyses of randomised controlled trials
- Xue-Li Bai1,
- Yu Li2,3,
- Zan-Fei Feng2,3,
- Fan Cao4,5,
- Dong-Dong Wang3,4,
- Jing Ma2,
- Dan Yang2,3,
- Dong-Run Li4,5,
- Qian Fang3,4,5,
- Ying Wang2,3,
- Xiao-Feng Jiang1,
- Dong-Hui Huang4,5,
- Xiao-Ying Li4,5,
- Jia-Kai Guo6,
- Na Zhao7,
- Zhi-Tong Li8,
- Qi-Peng Ma2,
- Lei Wang2,
- http://orcid.org/0000-0001-9421-5114Qi-Jun Wu2,3,4,5,9,
- Ting-Ting Gong2
- 1Department of Obstetrics and Gynecology, Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
- 2Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- 3Department of Epidemiology, China Medical University School of Public Health, Shenyang, Liaoning, China
- 4Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- 5Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- 6Hospital Management Office, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- 7Department of Clinical Laboratory, Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning, China
- 8Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- 9NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University), National Health Commission, Shenyang, China
- Correspondence to Dr Qi-Jun Wu; wuqj{at}sj-hospital.org; Dr Ting-Ting Gong; gongtt{at}sj-hospital.org; Dr Lei Wang; wangl6{at}sj-hospital.org; Dr Qi-Peng Ma; maqipeng1985{at}163.com
Abstract
Objective To examine the comprehensive health impacts of exercise on people with cancer by systematically summarising existing evidence and assessing the strength and reliability of the associations.
Design Umbrella review of meta-analyses.
Data source PubMed, Embase, Cochrane and Web of Science databases were searched from their inception to 23 July 2024.
Eligibility criteria for selecting studies Meta-analyses of randomised controlled trials that investigated the associations between exercise and health outcomes among people with cancer.
Results This umbrella review identified 485 associations from 80 articles, all evaluated as moderate to high quality using A Measurement Tool to Assess Systematic Reviews (AMSTAR). Two hundred and sixty (53.6%) associations were statistically significant (p<0.05), 81/485 (16.7%) were supported by high-certainty evidence according to the Grading of Recommendations Assessment, Development, and Evaluation criteria. Compared with usual care or no exercise, moderate- to high-certainty evidence supported the view that exercise significantly mitigates adverse events associated with cancer and its treatments (eg, cardiac toxicity, chemotherapy-induced peripheral neuropathy, cognitive impairment and dyspnoea). Exercise also modulates body composition and biomarkers (eg, insulin, insulin-like growth factor-1, insulin-like growth factor-binding protein-1 and C-reactive protein) in people with cancer, and enhances sleep quality, psychological well-being, physiological functioning and social interaction, while improving overall quality of life.
Conclusion Exercise reduces adverse events and enhances well-being through a range of health outcomes in people with cancer.
- Meta-analysis
- Exercise
- Randomised Controlled Trial
- Review
Data availability statement
Data are available upon reasonable request.
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- Meta-analysis
- Exercise
- Randomised Controlled Trial
- Review
Data availability statement
Data are available upon reasonable request.
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Footnotes
X-LB, YL, Z-FF and FC contributed equally.
Contributors X-LB, YL, Q-JW and T-TG contributed to the study design. X-LB, YL, Z-FF, JM, DY, D-RL, QF and YW collection of data. X-LB, YL, Z-FF, X-FJ, Z-TL, D-HH, J-KG, NZ and X-YL analysis of data. X-LB, YL, Z-FF, FC, D-DW, Q-PM, LW, Q-JW and T-TG wrote the first draft of the manuscript and edited the manuscript. All authors read and approved the final manuscript. X-LB, YL, Z-FF and FC contributed equally to this work. Q-JW was the study guarantor.
Funding This work was supported by the Natural Science Foundation of China (No. 82373674 to Q-JW and No. 82103914 to T-TG), Scientific Research Project of Education Department of Liaoning Province (No. LJKMZ20221137 to T-TG), Liaoning Province Science and Technology Plan (No. 2023JH2/20200019 to QJ-W), Youth Scientist Program of the Liaoning Provincial Department of Education (No. LJ212410159082 to X-LB), Shenyang Science and Technology Plan (Medical-Engineering Integration) (No. 24-214-3-22 to Gong TT), Outstanding Scientific Fund of Shengjing Hospital (QJ-W) and Liaoning Province Livelihood Science and Technology Plan Project (2021JH2/10300040).
Competing interests None declared.
Provenance and peer review Not commissioned; externally peer reviewed.
Supplemental material This content has been supplied by the author(s). It has not been vetted by BMJ Publishing Group Limited (BMJ) and may not have been peer-reviewed. Any opinions or recommendations discussed are solely those of the author(s) and are not endorsed by BMJ. BMJ disclaims all liability and responsibility arising from any reliance placed on the content. Where the content includes any translated material, BMJ does not warrant the accuracy and reliability of the translations (including but not limited to local regulations, clinical guidelines, terminology, drug names and drug dosages), and is not responsible for any error and/or omissions arising from translation and adaptation or otherwise.
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